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GNAO1 Antibody (PA5-97796) in WB
Western Blot analysis of GNAO1 using a GNAO1 Polyclonal antibody (Product # PA5-97796) at a concentration of 3 µg/mL. Positive WB detected in: Rat brain tissue, Mouse brain tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 41 kDa.
产品信息
PA5-97796
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Mouse Guanine nucleotide-binding protein G(o) subunit alpha protein (2-354AA)
偶联物
形式
Liquid
浓度
4 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812411
靶标信息
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686O0962; G alpha o; GNAO 1; Go alpha; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha
基因别名: alphaO; AW050213; Galphao; Gna0; Gnao; Gnao1; RATBPGTPC
UniProt ID: (Rat) P59215, (Mouse) P18872
Entrez Gene ID: (Rat) 50664, (Mouse) 14681
GTPase activity
signal transducer activity
protein binding
GTP binding
GDP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
mu-type opioid receptor binding
protein complex binding
GTPase activating protein binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
nucleotide binding
guanyl nucleotide binding
heterotrimeric G-protein
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
dopamine receptor signaling pathway
aging
locomotory behavior
regulation of heart contraction
metabolic process
cellular process
response to organonitrogen compound
response to organic cyclic compound
forebrain development
neuron projection development
response to cytokine
response to drug
response to hydrogen peroxide
response to morphine
positive regulation of GTPase activity
negative regulation of calcium ion transport
signal transduction
