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产品信息
PA5-25238
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 580-607 amino acids from the C-terminal region of human GNE
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2542738
产品详细信息
This antibody is predicted to react with hamster and rat based on sequence homology.
靶标信息
GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; ManAc kinase; N-acetylmannosamine kinase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase (hydrolyzing); UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; Uridine diphosphate-N-acetylglucosamine-2-epimerase
基因别名: 2310066H07Rik; DMRV; GLCNE; GNE; IBM2; NM; Uae1
UniProt ID: (Human) Q9Y223, (Mouse) Q91WG8
Entrez Gene ID: (Human) 10020, (Mouse) 50798
hydrolase activity, hydrolyzing O-glycosyl compounds
protein binding
ATP binding
UDP-N-acetylglucosamine 2-epimerase activity
N-acylmannosamine kinase activity
metal ion binding
nucleotide binding
catalytic activity
kinase activity
transferase activity
phosphotransferase activity, alcohol group as acceptor
hydrolase activity
