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产品信息
PA5-65982
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664752
产品详细信息
Immunogen sequence: GSSEDDAQSRR DEQDDDDKGD SKETRLTLME E
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 94%.
靶标信息
GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coat protein GPP34; coat-protein; golgi peripheral membrane protein 1, 34 kDa; Golgi phosphoprotein 3; golgi phosphoprotein 3 (coat-protein); golgi protein; golgi-associated protein; MIDAS; Mitochondrial DNA absence factor
基因别名: GOLPH3; GOPP1; GPP34; MIDAS; Vps74
UniProt ID: (Human) Q9H4A6
Entrez Gene ID: (Human) 64083
Golgi organization
cell proliferation
glycoprotein biosynthetic process
protein secretion
gene expression
regulation of mitochondrion organization
cell migration
lamellipodium assembly
positive regulation of TOR signaling
Golgi to plasma membrane protein transport
negative regulation of apoptotic process
protein retention in Golgi apparatus
Golgi vesicle budding
positive regulation of protein secretion
leukocyte tethering or rolling
cell adhesion molecule production
Golgi ribbon formation
asymmetric Golgi ribbon formation
