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GP1BA Antibody (H00002811-D01P) in WB
Western Blot analysis of GP1BA expression in transfected 293T cell line (H00002811-T01) by GP1BA MaxPab polyclonal antibody.
Lane 1: GP1BA transfected lysate(69.00 KDa).
Lane 2: Non-transfected lysate.
Lane 1: GP1BA transfected lysate(69.00 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00002811-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GP1BA (AAH27955.1, 1 a.a. approximately 626 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT ILHLSENLLY TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL SHNQLQSLPL LGQTLPALTV LDVSFNRLTS LPLGALRGLG ELQELYLKGN ELKTLPPGLL TPTPKLEKLS LANNNLTELP AGLLNGLENL DTLLLQENSL YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA ENVYVWKQGV DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK EQTTFPPRWT PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT TLEPTPSPTT PEPTSEPAPS PTTPEPTPIP TIATSPTILV SATSLITPKS TFLTTTKPVS LLESTKKTIP ELDQPPKLRG VLQGHLESSR NDPFLHPDFC CLLPLGFYVL GLFWLLFASV VLILLLSWVG HVKPQALDSG QGAALTTATQ TTHLELQRGR QVTVPRAWLL FLRGSLPTFR SSLFLWVRPN GRLGPLVAGR RPSALSQGRG QDLLSTVSIR YSGHSL
靶标信息
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen CD42b-alpha; CD42a; CD42b; glycoprotein Ib (platelet), alpha polypeptide; GP-Ib alpha; GP-IX; GPIB; GPIb alpha; GPIX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; Platelet glycoprotein Ib alpha chain; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha
基因别名: BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GP1BA; GPIbA; GPIbalpha; VWDP
UniProt ID: (Human) P07359
Entrez Gene ID: (Human) 2811
cell morphogenesis
negative regulation of protein kinase activity
cell adhesion
cell surface receptor signaling pathway
blood coagulation
blood coagulation, intrinsic pathway
cytokine-mediated signaling pathway
platelet activation
regulation of blood coagulation
fibrinolysis
negative regulation of JAK-STAT cascade
thrombin receptor signaling pathway
