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Product Details
PA5-20524
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the carboxy terminus of the human GPAT1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155813
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-20524 can be used with blocking peptide PEP-0644.
Target Information
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: glycerol 3-phosphate acyltransferase, mitochondrial; Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT-1; P90; RP11-426E5.2
Gene Aliases: GPAM; GPAT; GPAT1; KIAA1560
UniProt ID: (Human) Q9HCL2, (Mouse) Q61586, (Rat) P97564
Entrez Gene ID: (Human) 57678, (Mouse) 14732, (Rat) 29653
lipid metabolic process
fatty acid metabolic process
acyl-CoA metabolic process
triglyceride metabolic process
glycerophospholipid metabolic process
metabolic process
phospholipid biosynthetic process
response to glucose
positive regulation of triglyceride biosynthetic process
response to activity
triglyceride biosynthetic process
cellular response to insulin stimulus
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
cellular lipid metabolic process
regulation of cytokine secretion
defense response to virus
fatty acid homeostasis
phospholipid homeostasis
negative regulation of activation-induced cell death of T cells
interleukin-2 secretion
response to fructose
CDP-diacylglycerol biosynthetic process
response to nutrient levels
response to cadmium ion
phosphatidic acid biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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