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产品信息
PA5-34037
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 20 amino acid peptide from C-terminus of human O3FAR1 / GPR120.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551395
产品详细信息
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey, Marmoset (95%) Gibbon (89%).
靶标信息
An EST for GPR120 has been isolated from a human colon cancer library. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Free fatty acid receptor 4; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; GPCR120; Omega-3 fatty acid receptor 1
基因别名: BMIQ10; FFAR4; GPR120; GPR129; GT01; O3FAR1; PGR4
UniProt ID: (Human) Q5NUL3
Entrez Gene ID: (Human) 338557
G-protein coupled receptor signaling pathway
regulation of glucose transport
cellular response to hormone stimulus
negative regulation of apoptotic process
fat cell differentiation
hormone secretion
negative regulation of cytokine secretion
negative regulation of inflammatory response
detection of chemical stimulus involved in sensory perception of taste
positive regulation of ERK1 and ERK2 cascade
response to peptide
