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产品信息
PA5-118809
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GPR37(Accession O15354), corresponding to amino acid residues F556-F606.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903309
产品详细信息
Antibody detects endogenous levels of total GPR37.
靶标信息
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor 37; G-protein coupled receptor CNS1; Gpcr/cns1; Het-b-r-lp; Pael receptor; PAELR; parkin-associated endothelin B-like receptor; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; Prosaposin receptor GPR37
基因别名: AI848630; EDNRBL; GPR37; hET(B)R-LP; Pael-R; PAELR
UniProt ID: (Human) O15354, (Mouse) Q9QY42, (Rat) Q9QYC6
Entrez Gene ID: (Human) 2861, (Mouse) 14763, (Rat) 117549
G-protein coupled receptor activity
protein binding
G-protein coupled peptide receptor activity
Hsp70 protein binding
heat shock protein binding
ubiquitin protein ligase binding
prosaposin receptor activity
peptide binding
signal transducer activity
G-protein coupled receptor
transmembrane signal receptor
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
locomotion involved in locomotory behavior
dopamine biosynthetic process
positive regulation of MAPK cascade
positive regulation of dopamine metabolic process
negative regulation of hydrogen peroxide-induced cell death
signal transduction
