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产品信息
PA5-66932
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2663227
产品详细信息
Immunogen sequence: VHGHFQPTQTG FLQPGGALSL QKQMEHANQQ TGFSDSSSLR PMHPQALHPA PGLLASPQLP VQMQPAGKSG FAATSQPGPR LPFIQHSQNP RFYHK
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 95%.
靶标信息
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein pathway suppressor 2; GPS-2
基因别名: AMF-1; GPS2
UniProt ID: (Human) Q13227
Entrez Gene ID: (Human) 2874
