Invitrogen

GREM1 Polyclonal Antibody

查看其他15个GREM1抗体

产品信息

PA5-70341

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

-

产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the middle region of rat GREM1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2691293

产品详细信息

This target displays homology in the following species: Cow: 92%; Dog: 100%; Goat: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Zebrafish: 93%

靶标信息

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; gremlin 1 homolog, cysteine knot superfamily; Gremlin-1

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基因别名: Cktsf1b1; Drm; Grem; Grem1; ld

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UniProt ID: (Rat) O35793, (Mouse) O70326

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Entrez Gene ID: (Rat) 50566, (Mouse) 23892

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cytokine activity protein binding transmembrane receptor protein tyrosine kinase activator activity vascular endothelial growth factor receptor 2 binding receptor agonist activity heparan sulfate proteoglycan binding

cell morphogenesis angiogenesis branching involved in ureteric bud morphogenesis cell migration involved in sprouting angiogenesis positive regulation of receptor internalization negative regulation of leukocyte chemotaxis positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation mesenchymal to epithelial transition involved in metanephros morphogenesis apoptotic process signal transduction activation of transmembrane receptor protein tyrosine kinase activity cell-cell signaling positive regulation of cell proliferation organ morphogenesis proximal/distal pattern formation regulation of epithelial to mesenchymal transition collagen fibril organization negative regulation of cell growth embryonic limb morphogenesis negative regulation of bone mineralization negative regulation of BMP signaling pathway negative regulation of chondrocyte differentiation regulation of stress-activated MAPK cascade negative regulation of osteoblast proliferation positive regulation of NF-kappaB import into nucleus negative regulation of apoptotic process endothelial cell migration positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of bone remodeling determination of dorsal identity positive regulation of NF-kappaB transcription factor activity regulation of focal adhesion assembly positive regulation of telomerase activity limb development negative regulation of pathway-restricted SMAD protein phosphorylation ureteric bud formation positive regulation of protein tyrosine kinase activity signal transduction by p53 class mediator negative regulation of monocyte chemotaxis negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of osteoclast proliferation positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of bone trabecula formation negative regulation of bone mineralization involved in bone maturation positive regulation of receptor activity positive regulation of cardiac muscle cell differentiation