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GRHL2 Antibody (PA5-87681) in WB
Western blot analysis of GRHL2 in extracts of various cell lines. Samples were incubated with GRHL2 Polyclonal antibody (Product # PA5-87681) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-87681
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 80-250 of human GRHL2 (NP_0791912)
偶联物
形式
Liquid
浓度
1.99 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804342
产品详细信息
Immunogen sequence: LSVSKASDSQ EDQEKRNCLG TSEAQSNLSG GENRVQVLKT VPVNLSLNQD HLENSKREQY SISFPESSAI IPVSGITVVK AEDFTPVFMA PPVHYPRGDG EEQRVVIFEQ TQYDVPSLAT HSAYLKDDQR STPDSTYSES FKDAATEKFR SASVGAEEYM YDQTSSGTFQ Y; Positive Samples: SH-SY5Y; Cellular Location: Membrane, Nucleus
靶标信息
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brother of mammalian grainyhead; grainyhead-like 2; Grainyhead-like protein 2 homolog; grainyhead-like transcription factor 2; Transcription factor CP2-like 3
基因别名: BOM; DFNA28; ECTDS; GRHL2; RGD1561191; TFCP2L3
UniProt ID: (Human) Q6ISB3
Entrez Gene ID: (Human) 79977, (Rat) 299979
intronic transcription regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
molecular_function
DNA-binding transcription factor
neural tube closure
cardiac ventricle morphogenesis
epithelial cell morphogenesis
transcription from RNA polymerase II promoter
cell adhesion
brain development
cell proliferation
epidermis development
neural tube development
cell junction assembly
multicellular organism growth
embryonic digit morphogenesis
camera-type eye development
regulation of DNA methylation
negative regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
positive regulation of telomerase activity
face development
lung lobe morphogenesis
lung epithelial cell differentiation
epithelial cell morphogenesis involved in placental branching
bicellular tight junction assembly
epithelium migration
in utero embryonic development
regulation of transcription from RNA polymerase II promoter
biological_process
regulation of gene expression
respiratory tube development
embryonic organ development
