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GRID2 Antibody (PA5-115325) in IHC (P)
Immunohistochemistry analysis of GRID2 in mouse testis tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115325) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115325
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GRID2(Accession O43424), corresponding to amino acid residues A840-S890.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899961
产品详细信息
Antibody detects endogenous levels of total GRID2.
靶标信息
GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: creeper; GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10
基因别名:
B230104L07Rik; cpr; GluD2; GLURD2; GluRdelta2; GRID2; ho; Lc; Lc
UniProt ID: (Human) O43424, (Mouse) Q61625, (Rat) Q63226
Entrez Gene ID: (Human) 2895, (Mouse) 14804, (Rat) 79220
transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
glutamate receptor signaling pathway
regulation of neuron projection development
cerebellar granule cell differentiation
ion transmembrane transport
cellular protein localization
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of neuron apoptotic process
excitatory postsynaptic potential
prepulse inhibition
ion transport
biological_process
