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产品信息
PA5-63274
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642216
产品详细信息
Immunogen sequence: RVPSKEDDKE IDLEHLHRRV NSLCTDDDSP HKQFSTSSID LTPLDIDTLP TRQALEQISD FRNTHITTTT FIPEQIQTLS RTLSAKAASG FTFGNVPEHR TGPFRHRAPN GGFFRSPIKT MSSIPYQPTP TLGLNLGNDP DR
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
靶标信息
GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
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生物信息学
蛋白别名: GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2
基因别名: GluD2; GLURD2; GRID2; SCAR18
UniProt ID: (Human) O43424
Entrez Gene ID: (Human) 2895
transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
glutamate receptor signaling pathway
regulation of neuron projection development
cerebellar granule cell differentiation
ion transmembrane transport
cellular protein localization
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of neuron apoptotic process
excitatory postsynaptic potential
prepulse inhibition
