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GRID2 (extracellular) Antibody (AGC-039-200UL) in ICC/IF
Expression of Glutamate receptor delta 2 in rat PC12 cells - Cell surface detection of GluD2 in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells with Anti-GRID2 (extracellular) Antibody (#AGC-039), (1:50), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells. C. Merge of A and B. Cell nuclei (blue) were visualized with Hoechst 33342.
产品信息
AGC-039-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KMITTLFDTMRIE, corresponding to amino acid residues 206-218 of rat GluD2, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: creeper; GluD2; gluR delta-2 subunit; glutamate receptor; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10
基因别名:
B230104L07Rik; cpr; GluD2; GLURD2; GluRdelta2; GRID2; ho; Lc; Lc
UniProt ID: (Human) O43424, (Mouse) Q61625, (Rat) Q63226
Entrez Gene ID: (Human) 2895, (Mouse) 14804, (Rat) 79220
transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
glutamate receptor signaling pathway
regulation of neuron projection development
cerebellar granule cell differentiation
ion transmembrane transport
cellular protein localization
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of neuron apoptotic process
excitatory postsynaptic potential
prepulse inhibition
ion transport
biological_process
