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Product Details
H00002870-M06
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2G1
Immunogen
GRK6 (AAH17272, 71 a.a. approximately 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF
Target Information
GRK6 is a member of the guanine nucleotide-binding protein coupled receptor kinase subfamily of the serine/threonine protein kinase family. GRK6 phosphorylates the activated forms of G protein-coupled receptors to initiate their deactivation. Several transcript variants encoding different isoforms have been described for GRK6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.11.16; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; G-protein coupled receptor kinase 6; kinase GRK6
Gene Aliases: GPRK6; GRK6
UniProt ID: (Human) P43250, (Mouse) O70293
Entrez Gene ID: (Human) 2870, (Mouse) 26385, (Rat) 59076
G-protein coupled receptor kinase activity
protein binding
ATP binding
beta-adrenergic receptor kinase activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
desensitization of G-protein coupled receptor protein signaling pathway
protein phosphorylation
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of anion channel activity
Wnt signaling pathway
signal transduction
phosphorylation
termination of G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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