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产品信息
OPA1-15619
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, conjugated to KLH, corresponding to the 2nd extracellular loop of human GRPR.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2114349
产品详细信息
Recommended positive controls: Human pancreas, islets of Langerhans.
By immunohistochemistry, OPA1-15619 detects GRPR in formalin fixed, paraffin embedded human tissues.
靶标信息
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bombesin receptor 2; Gastrin-releasing peptide receptor; GRP receptor; GRP-preferring bombesin receptor; GRP-R
基因别名: BB2; BB2R; GRPR
UniProt ID: (Human) P30550
Entrez Gene ID: (Human) 2925
