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GSTM3 Antibody (PA5-79338) in IHC (P)
Immunohistochemistry analysis of GSTM3 on paraffin-embedded human rectal cancer tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with GSTM3 polyclonal antibody (Product# PA5-79338) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). ... View More
产品信息
PA5-79338
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human GSTM3 recombinant protein (Position: E93-Q206).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2746454
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Glutathione S-transferase M3 (brain), also known as GSTM3, is an enzyme which in humans is encoded by theGSTM3 gene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13. 3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain GST; brain type mu-glutathione S-transferase; glutathione S-alkyltransferase M3; glutathione S-aralkyltransferase M3; glutathione S-aryltransferase M3; Glutathione S-transferase GT9.3; glutathione S-transferase M3 (brain); Glutathione S-transferase Mu 3; glutathione S-transferase mu 3 (brain); glutathione S-transferase, Mu-3; GST class-mu 3; GSTM3-3; hGSTM3-3; S-(hydroxyalkyl)glutathione lyase M3
基因别名: Fsc2; GST5; GSTB; GSTM3; GSTM3-3; GTM3; mGSTM5
UniProt ID: (Human) P21266, (Mouse) P19639
Entrez Gene ID: (Human) 2947, (Mouse) 14864
glutathione metabolic process
establishment of blood-nerve barrier
nitrobenzene metabolic process
xenobiotic catabolic process
response to estrogen
cellular detoxification of nitrogen compound
glutathione derivative biosynthetic process
metabolic process
cellular response to drug
cellular response to organic cyclic compound
