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GTF2A2 Antibody (PA5-103306) in IHC (P)
Immunohistochemistry analysis of GTF2A2 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GTF2A2 polyclonal antibody (Product # PA5-103306) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-103306
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GTF2A2(Accession P52657), corresponding to amino acid residues Q27-N77.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852651
产品详细信息
Antibody detects endogenous levels of total TF2A2.
靶标信息
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: general transcription factor IIA 2; General transcription factor IIA subunit 2; general transcription factor IIA, 2 (12kD subunit); general transcription factor IIA, 2, 12kDa; TFIIA gamma subunit; TFIIA p12 subunit; TFIIA-12; TFIIA-gamma; Transcription initiation factor IIA gamma chain; Transcription initiation factor IIA subunit 2
基因别名: GTF2A2; HsT18745; T18745; TF2A2; TFIIA; TFIIA-12; TFIIA-gamma; Tfiia2; TFIIAS; TfIIg
UniProt ID: (Human) P52657, (Mouse) Q80ZM7, (Rat) O08950
Entrez Gene ID: (Human) 2958, (Mouse) 235459, (Rat) 83828
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
viral process
snRNA transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
RNA polymerase II transcriptional preinitiation complex assembly
transcription, DNA-templated
regulation of transcription, DNA-templated
