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NeoBiotechnologies
GTF2H2/BTF2/TFIIH Basal Transcription Factor Monoclonal Antibody (PCRP-GTF2H2-1B9)
FIGURE: 1 / 5
GTF2H2/BTF2/TFIIH Basal Transcription Factor Antibody (2966-MSM1-P1) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of PFA-fixed MCF7 cells using GTF2H2, BTF2, TFIIH Basal Transcription Factor Monoclonal Antibody (Product # 2966-MSM1-P1) followed by goat anti-mouse IgG-CF488 (green). Phalloidin counterstain (red)..
Product Details
2966-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
PCRP-GTF2H2-1B9
Immunogen
Recombinant full-length human GTF2H2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Basic transcription factor 2 44 kDa subunit; BTF2 p44; General transcription factor IIH polypeptide 2; General transcription factor IIH subunit 2; general transcription factor IIH, polypeptide 2, 44kD subunit; general transcription factor IIH, polypeptide 2, 44kDa; TFIIH basal transcription factor complex p44 subunit
Gene Aliases: BTF2; BTF2P44; GTF2H2; p44; T-BTF2P44; TFIIH
UniProt ID: (Human) Q13888
Entrez Gene ID: (Human) 2966
nucleic acid binding
transcription factor activity, sequence-specific DNA binding
protein kinase activity
protein binding
DNA-dependent ATPase activity
translation factor activity, RNA binding
zinc ion binding
RNA polymerase II carboxy-terminal domain kinase activity
protein N-terminus binding
RNA metabolism protein
nucleic acid metabolism protein
general transcription factor
nucleotide-excision repair, DNA duplex unwinding
G-protein coupled receptor internalization
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
translation
protein phosphorylation
response to UV
nucleotide-excision repair, DNA incision
global genome nucleotide-excision repair
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