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GTF2H4 Antibody (PA5-103346) in IHC (P)
Immunohistochemistry analysis of GTF2H4 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GTF2H4 polyclonal antibody (Product # PA5-103346) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GTF2H4(Accession Q92759), corresponding to amino acid residues L108-V158.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852691
Product Specific Information
Antibody detects endogenous levels of total GTF2H4.
Target Information
GTF2H4 belongs to the TFB2 family. It is a component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; General transcription factor IIH subunit 4; general transcription factor IIH, polypeptide 4, 52kDa; TFIIH basal transcription factor complex p52 subunit; TFIIH transcription/DNA repair factor p52 subunit
Gene Aliases: AW545633; BTF2 p52; GTF2H4; P52; TFB2; TFIIH
UniProt ID: (Human) Q92759, (Mouse) O70422
Entrez Gene ID: (Human) 2968, (Rat) 294236, (Mouse) 14885
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
ATP-dependent DNA helicase activity
protein kinase activity
protein binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
RNA metabolism protein
nucleic acid metabolism protein
general transcription factor
nucleotide-excision repair, DNA duplex unwinding
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
nucleotide-excision repair, DNA incision
phosphorylation of RNA polymerase II C-terminal domain
global genome nucleotide-excision repair
protein phosphorylation
DNA duplex unwinding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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