Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 10
GTPBP4 Antibody (PA5-85296) in ICC/IF
GTPBP4 Polyclonal Antibody detects GTPBP4 protein at nucleolus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: GTPBP4 protein stained by GTPBP4 Polyclonal Antibody (Product # PA5-85296) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-85296
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human GTPBP4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792439
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (91%), Rat (91%), Chicken (83%), Bovine (89%).
Positive Control: 293T, A431, HeLa, HepG2, Neuro 2A, GL261, C8D30, NIH-3T3, BCL-1, C2C12, PC-12, Rat2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Chronic renal failure gene protein; chronic renal failure protein; FLJ10686; FLJ10690; FLJ39774; G protein-binding protein CRFG; GTP binding protein 3; GTP-binding protein 4; GTP-binding protein NGB; Nucleolar GTP-binding protein 1; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
基因别名: 2610028C09Rik; CRFG; Gtpbp3; GTPBP4; NGB; NOG1
UniProt ID: (Human) Q9BZE4, (Mouse) Q99ME9
Entrez Gene ID: (Human) 23560, (Mouse) 69237, (Rat) 114300
regulation of cyclin-dependent protein serine/threonine kinase activity
osteoblast differentiation
metabolic process
negative regulation of DNA replication
negative regulation of cell proliferation
negative regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of protein ubiquitination
negative regulation of collagen binding
ribosome biogenesis
protein stabilization
