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GTPBP4 Antibody (MA5-34853) in IHC (P)
Immunohistochemistry analysis of GTPBP4 in paraffin-embedded human thyroid gland tissue. Samples were heat mediated antigen retrieval with sodium citrate buffer (pH 6.0, 20 min) and blocked in 5% BSA (30 min, room temperature), incubated with GTPBP4 monoclonal antibody (Product # MA5-34853) at a dilution of 1:50 (30 min, room temperature), and followed by HRP conjugated compact polymer system, DAB, counters... View More
产品信息
MA5-34853
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE47-47
抗原
Recombinant protein within Human GTPBP4 aa 1-131
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
RRID
AB_2848761
产品详细信息
Positive Control: 293T cell, human liver cancer tissue, human thyroid gland tissue, human skin tissue, human breast tissue, thp-1.
靶标信息
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chronic renal failure gene protein; FLJ10686; FLJ10690; FLJ39774; G protein-binding protein CRFG; GTP-binding protein 4; GTP-binding protein NGB; Nucleolar GTP-binding protein 1
基因别名: CRFG; GTPBP4; NGB; NOG1
UniProt ID: (Human) Q9BZE4
Entrez Gene ID: (Human) 23560
regulation of cyclin-dependent protein serine/threonine kinase activity
osteoblast differentiation
negative regulation of DNA replication
negative regulation of cell proliferation
negative regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of protein ubiquitination
negative regulation of collagen binding
ribosome biogenesis
protein stabilization
