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产品信息
PA5-88718
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GUCY1A3 (NP_0008472)
偶联物
形式
Liquid
浓度
0.73 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805087
产品详细信息
Immunogen sequence: MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE; Positive Samples: U-87MG, A-549, 293T, Mouse kidney, Mouse brain, Rat kidney, Rat spleen, Rat lung; Cellular Location: Cytoplasm
靶标信息
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4.6.1.2; alpha 1 sGC; GC-S-alpha-1; GCS-alpha-1; GCS-alpha-3; GCS-alpha1; GCSalpha1; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); GUCY1A1; Soluble guanylate cyclase large subunit
基因别名: 1200016O07Rik; GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; GUCY1A3; MYMY6; SGC; sGC-alpha1
UniProt ID: (Human) Q02108, (Mouse) Q9ERL9
Entrez Gene ID: (Human) 2982, (Mouse) 60596, (Rat) 497757
cGMP biosynthetic process
nitric oxide mediated signal transduction
blood circulation
regulation of blood pressure
response to herbicide
response to organic cyclic compound
positive regulation of cGMP biosynthetic process
response to defense-related host nitric oxide production
relaxation of vascular smooth muscle
cyclic nucleotide biosynthetic process
intracellular signal transduction
