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产品信息
MA5-17086
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Non-human primate
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3G6B2
抗原
Purified recombinant fragment of human GUCY1A3 (amino acids: 22-214) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538557
产品详细信息
MA5-17086 targets GUCY1A3 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17086 immunogen is purified recombinant fragment of human GUCY1A3 (amino acids: 22-214) expressed in E. Coli.
MA5-17086 detects GUCY1A3 which has a predicted molecular weight of approximately 77.5kDa.
靶标信息
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 4.6.1.2; GC-S-alpha-1; GCS-alpha-1; GCS-alpha-3; GCS-alpha1; GCSalpha1; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; GUCY1A1; Soluble guanylate cyclase large subunit
基因别名: GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; GUCY1A3; MYMY6
UniProt ID: (Human) Q02108
Entrez Gene ID: (Human) 2982
cGMP biosynthetic process
nitric oxide mediated signal transduction
blood circulation
regulation of blood pressure
response to herbicide
response to organic cyclic compound
positive regulation of cGMP biosynthetic process
response to defense-related host nitric oxide production
relaxation of vascular smooth muscle
