Invitrogen

GZMB/GZMH Polyclonal Antibody

GZMB/GZMH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GZMB/GZMH Antibody (PA5-115323) in IHC (P)

Immunohistochemistry analysis of GZMB/GZMH in human normal tissues adjacent to pancreatic cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115323) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.

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产品信息

PA5-115323

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human GZMB(Accession P10144), corresponding to amino acid residues M1-G50.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2899959

产品详细信息

Antibody detects endogenous levels of total Granzyme B/H.

靶标信息

GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C11; Cathepsin G-like 1; Cathepsin G-like 2; cathepsin G-like 2, protein h-CCPX; CCP-X; CCP1; CGL-2; CGL2; CSP-C; CTLA-1; CTLA1; CTSGL1; CTSGL2; Cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; Cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; cytotoxin serine protease-C; Fragmentin; fragmentin 2; Fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; Granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme B(G,H); Granzyme H; granzyme H (cathepsin G-like 2, protein h-CCPX); Granzyme-2; granzyme-like protein 1; granzyme-like protein I; GZMH; GZMH/GZMB; HLP; Human lymphocyte protein; Lymphocyte protease; Natural killer cell protease 1; RNKP-1; SECT; T-cell serine protease 1-3E

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基因别名: AI553453; CCP-1/C11; CCP-X; CCP1; CCPI; CGL-1; CGL-2; CGL1; CGL2; CSP-B; CSP-C; CSPB; Ctla-1; CTLA1; CTSGL1; CTSGL2; GRB; GZB; GZMB; GZMH; HLP; RNKP-1; SECT