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Gelsolin Antibody (MA5-51343) in IHC (P)
Immunohistochemistry analysis of Gelsolin in paraffin-embedded human liver cancer. Samples were incubated with Gelsolin Recombinant monoclonal antibody (Product # MA5-51343) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
MA5-51343
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
0N10G5
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 28-782 of human Gelsolin (NP_000168.1).
偶联物
形式
Liquid
浓度
0.07 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_3093021
产品详细信息
Immunogen sequence: ATASRGASQA GAPQGRVPEA RPNSMVVEHP EFLKAGKEPG LQIWRVEKFD LVPVPTNLYG DFFTGDAYVI LKTVQLRNGN LQYDLHYWLG NECSQDESGA AAIFTVQLDD YLNGRAVQHR EVQGFESATF LGYFKSGLKY KKGGVASGFK HVVPNEVVVQ RLFQVKGRRV VRATEVPVSW ESFNNGDCFI LDLGNNIHQW CGSNSNRYER LKATQVSKGI RDNERSGRAR VHVSEEGTEP EAMLQVLGPK PALPAGTEDT AKEDAANRKL AKLYKVSNGA GTMSVSLVAD ENPFAQGALK SEDCFILDHG KDGKIFVWKG KQANTEERKA ALKTASDFIT KMDYPKQTQV SVLPEGGETP LFKQFFKNWR DPDQTDGLGL SYLSSHIANV ERVPFDAATL HTSTAMAAQH GMDDDGTGQK QIWRIEGSNK VPVDPATYGQ FYGGDSYIIL YNYRHGGRQG QIIYNWQGAQ STQDEVAASA ILTAQLDEEL GGTPVQSRVV QGKEPAHLMS LFGGKPMIIY KGGTSREGGQ TAPASTRLFQ VRANSAGATR AVEVLPKAGA LNSNDAFVLK TPSAAYLWVG TGASEAEKTG AQELLRVLRA QPVQVAEGSE PDGFWEALGG KAAYRTSPRL KDKKMDAHPP RLFACSNKIG RFVIEEVPGE LMQEDLATDD VMLLDTWDQV FVWVGKDSQE EEKTEALTSA KRYIETDPAN RDRRTPITVV KQGFEPPSFV GWFLGWDDDY WSVDPLDRAM AELAA
靶标信息
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Actin-depolymerizing factor; ADF; ADFBrevin; AGEL; Brevin; DKFZp313L0718; Gelsolin; RP11-477J21.1
基因别名: ADF; AGEL; GSN
UniProt ID: (Human) P06396
Entrez Gene ID: (Human) 2934
phagocytosis, engulfment
aging
positive regulation of gene expression
oligodendrocyte development
striated muscle atrophy
extracellular matrix disassembly
actin filament polymerization
protein destabilization
tissue regeneration
sequestering of actin monomers
cellular protein metabolic process
actin nucleation
response to ethanol
negative regulation of viral entry into host cell
phosphatidylinositol-mediated signaling
actin filament severing
barbed-end actin filament capping
positive regulation of actin nucleation
response to folic acid
actin filament capping
cilium morphogenesis
cellular response to cadmium ion
regulation of podosome assembly
actin filament reorganization
renal protein absorption
hepatocyte apoptotic process
positive regulation of keratinocyte apoptotic process
regulation of wound healing, spreading of epidermal cells
regulation of establishment of T cell polarity
regulation of plasma membrane raft polarization
regulation of receptor clustering
positive regulation of protein processing in phagocytic vesicle
amyloid fibril formation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
