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Gemin 3 Antibody (MA5-31714) in ICC/IF
Immunocytochemistry analysis of Gemin 3 in HeLa cells (green). Sample was incubated with Gemin 3 monoclonal antibody (Product # MA5-31714) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
产品信息
MA5-31714
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C9F6
抗原
Purified recombinant fragment of human DDX20 (AA: 725-824) expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787338
产品详细信息
MA5-31714 has been tested in indirect ELISA.
靶标信息
Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Component of gems 3; DDX 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD-box protein DP103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD/H BOX 20; DKFZP434H052; DP 103; Gemin-3; Probable ATP-dependent RNA helicase DDX20; SMN-interacting protein
基因别名: DDX20; DP103; GEMIN3
UniProt ID: (Human) Q9UHI6
Entrez Gene ID: (Human) 11218, (Rat) 84473
negative regulation of transcription from RNA polymerase II promoter
spliceosomal tri-snRNP complex assembly
spliceosomal snRNP assembly
RNA processing
negative regulation of cell proliferation
RNA secondary structure unwinding
positive regulation of apoptotic process
oogenesis
regulation of steroid biosynthetic process
nuclear import
mRNA processing
RNA splicing
negative regulation of transcription, DNA-templated
