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Ghrelin Receptor (GHSR) (extracellular) Antibody (AGR-031-F-50UL) in Flow
Cell surface detection of Ghrelin receptor in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-Ghrelin Receptor (GHSR) (extracellular)-FITC Antibody (#AGR-031-F), (5 µg).
产品信息
AGR-031-F-50UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CRATEFAVRSG, corresponding to amino acid residues 197-207 of rat Ghrelin receptor, 2nd extracellular loop
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Growth hormone secretagogue receptor 1a (GHSR) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations to the gene can cause isolated partial growth hormone deficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein coupled receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; Ghrp receptor; GHS receptor; GHS-R; Growth hormone secretagogue receptor type 1
基因别名: C530020I22Rik; GHDP; GHSR
UniProt ID: (Human) Q92847, (Mouse) Q99P50, (Rat) O08725
Entrez Gene ID: (Human) 2693, (Mouse) 208188, (Rat) 84022
G-protein coupled receptor signaling pathway
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
growth hormone secretion
response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
cellular response to insulin stimulus
positive regulation of multicellular organism growth
negative regulation of tumor necrosis factor biosynthetic process
regulation of hindgut contraction
positive regulation of insulin-like growth factor receptor signaling pathway
negative regulation of interleukin-6 biosynthetic process
positive regulation of fatty acid metabolic process
negative regulation of insulin secretion
decidualization
negative regulation of inflammatory response
regulation of synapse assembly
signal transduction
