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产品信息
PA1-4660
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C-terminal region of rat GRIA2/3 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2279303
产品详细信息
This antibody is predicted to react with chicken, human, mouse and zebrafish based on 100% sequence homology.
This antibody is specific for the ~100 kDa GluR2/3 protein.
靶标信息
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; GluA2; GluA3; GluR-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; glutamate receptor B; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); GPRC1C; GRM3; MGR3
基因别名: GluA2; GluA3; GluR-3; gluR-B; GluR-C; GluR-K2; GluR-K3; GluR2; GLUR3; Gria2; Gria3
UniProt ID: (Rat) P19491, (Rat) P19492
Entrez Gene ID: (Rat) 29627, (Rat) 29628
receptor activity
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
calcium channel regulator activity
protein binding
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
regulation of receptor recycling
chemical synaptic transmission
response to lithium ion
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to fungicide
synaptic transmission, glutamatergic
