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GluR2/GluR3 Antibody (MA5-42796) in WB
Western blot analysis of GluR2/GluR3 in extracts of various cell lines. Samples were incubated with GluR2/GluR3 Monoclonal antibody (Product # MA5-42796) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
MA5-42796
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4K7G5
抗原
A synthetic peptide corresponding to a sequence within amino acids 784-883 of human GluR2+GluR3 (P42262).
偶联物
形式
Liquid
浓度
1.15 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911937
产品详细信息
Positive test controls include: Mouse brain, Rat brain.
Immunogen sequence: KNKWWYDKGE CGSGGGDSKE KTSALSLSNV AGVFYILVGG LGLAMLVALI EFCYKSRAEA KRMKVAKNAQ NINPSSSQNS QNFATYKEGY NVYGIESVKI
靶标信息
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; GluR-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; glutamate receptor B; glutamate receptor channel alpha3 subunit; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); GPRC1C; GRM3; MGR3
基因别名: 2900064I19Rik; GluA2; GluA3; Glur-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; GluR2; GLUR3; Gluralpha3; Gria2; Gria3; Kiaa4184
UniProt ID: (Rat) P19491, (Mouse) Q9Z2W9, (Rat) P19492
Entrez Gene ID: (Mouse) 14800, (Rat) 29627, (Mouse) 53623, (Rat) 29628
receptor activity
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
transmembrane signal receptor
regulation of receptor recycling
transport
ion transport
chemical synaptic transmission
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
