Invitrogen

GluR2/GluR3/GluR4 Polyclonal Antibody

GluR2/GluR3/GluR4 Antibody in Western Blot (WB)

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GluR2/GluR3/GluR4 Antibody (PA5-17314) in WB

Western blot analysis was performed on tissue extracts (30 µg lysate) of Mouse Brain (Lane 1), Rat Brain (Lane 2), Mouse Lung (Lane 3), Mouse Kidney (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Lung (Lane 6) and Rat Kidney (Lane 7). The blot was probed with Anti-GluR2/GluR3/GluR4 Polyclonal Antibody (Product # PA5-17314, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 100 kDa band corresponding to G... View More

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产品信息

PA5-17314

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues surrounding Ser720 of human GluR2

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

270 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_10985891

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.

Immunity

Roy ER,Chiu G,Li S,Propson NE,Kanchi R,Wang B,Coarfa C,Zheng H,Cao W

PA5-17314 was used in Western Blot to reveal brain-wide cellular reactions to type I interferon (IFN-I), an innate immune cytokine aberrantly elicited by amyloid β plaques, and examined their role in cognition and neuropathology relevant to AD in a murine amyloidosis model.

Tue May 10 00:00:00 UTC 2022

生物信息学

蛋白别名: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; AMPA-selective glutamate receptor 4; dJ1171F9.1; GluA4; GluR-2; GluR-3; GluR-4; GluR-B; GluR-C; GluR-D; GluR-K2; GluR-K3; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; Glutamate receptor 4; glutamate receptor B; glutamate receptor B flip isoform; glutamate receptor C; glutamate receptor channel alpha 4; glutamate receptor channel alpha3 subunit; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; Glutamate receptor ionotropic, AMPA 4; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA3 (alpha 3); glutamate receptor, ionotropic, AMPA4 (alpha 4); spike wave 1

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基因别名: 2900064I19Rik; GluA2; GluA3; GluA4; Glur-2; GluR-3; Glur-4; GluR-B; GLUR-C; GluR-D; GluR-K2; GLUR-K3; GLUR2; GLUR3; GLUR4; GLUR4C; Gluralpha3; Gluralpha4; GLURB; GLURC; GLURD; GRIA2; GRIA3; GRIA4; HBGR2; Kiaa4184; MRX94; spkw1