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NeoBiotechnologies
Glutathione S-Transferase Mu2 (GSTM2) Monoclonal Antibody (CPTC-GSTMu2-2)
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Glutathione S-Transferase Mu2 (GSTM2) Antibody (2946-MSM1-P1ABX) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of MeOH-fixed HeLa cells using Glutathione S-Transferase Mu2 (GSTM2) Monoclonal Antibody (Product # 2946-MSM1-P1ABX) followed by goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red)..
产品信息
2946-MSM1-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
CPTC-GSTMu2-2
抗原
Recombinant human full-length GSTMu2 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM2 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase M2; glutathione S-aryltransferase M2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-transferase M2 (muscle); Glutathione S-transferase Mu 2; GST class-mu 2; GST, muscle; GSTM2-2; MGC117303; S-(hydroxyalkyl)glutathione lyase M2
基因别名: GST4; GSTM; GSTM2; GSTM2-2; GTHMUS
UniProt ID: (Human) P28161
Entrez Gene ID: (Human) 2946
glutathione metabolic process
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
nitrobenzene metabolic process
xenobiotic catabolic process
linoleic acid metabolic process
relaxation of cardiac muscle
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
cellular detoxification of nitrogen compound
cellular response to caffeine
cellular oxidant detoxification
glutathione derivative biosynthetic process
