Invitrogen

Glypican 3 Recombinant Rabbit Monoclonal Antibody (024), FITC

Glypican 3 Antibody in Flow Cytometry (Flow)

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Glypican 3 Antibody (MA5-40987) in Flow

Flow cytometric analysis of Human Glypican 3 expression on HepG2 cells. Cells were stained with Glypican 3 Recombinant Rabbit Monoclonal Antibody (024), FITC (Product # MA5-40987). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

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产品信息

MA5-40987

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

024

抗原

A synthetic peptide corresponding to the center region of the Human Glypican 3/GPC3/OCI-5

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein A

保存液

PBS with 0.5% BSA

内含物

0.03% ProClin 300

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_2898748

产品详细信息

May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.

靶标信息

GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Soluble programmed death ligand-1-induced immunosuppressive effects on chimeric antigen receptor-natural killer cells targeting Glypican-3 in hepatocellular carcinoma.

Immunology

Chen L,Liu S,Adah D,Sun Q,Liang Z,Ho M,Sun B

MA5-40987 was used in Flow Cytometry to demonstrate that L3C7c-Fc could enhance the therapeutic effect of CAR-NK cells by reversing the suppression of sPD-L1, which provides the experimental evidence for the subsequent development of HCC immunotherapy strategies.