NeoBiotechnologies

Growth Hormone (Pituitary Marker) Monoclonal Antibody (rGH/1450)

Growth Hormone (Pituitary Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Growth Hormone (Pituitary Marker) Antibody (2688-MSM4-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human Pituitary stained with Growth Hormone Recombinant Mouse Monoclonal Antibody (rGH/1450).

Growth Hormone (Pituitary Marker) Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

2688-MSM4-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

rGH/1450

抗原

A recombinant fragment (around aa58-187) of human Growth Hormone (GH) protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.

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