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产品信息
MA5-24664
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM221
抗原
Acetyl-peptide corresponding to Acetyl-Histone H2A.Z (Lys4).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4, with 50% glycerol, 1% BSA
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2661888
产品详细信息
This antibody reacts to Histone H2A.Z acetylated at Lysine 4 (K4ac). No cross reactivity with non-modified Lysine 4 or other acetylated Lysines in histone H2A
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 11ac; Acetyl-Histone H2A.Z K4; Acetyl-Histone H2A.Z Lys4; H2A histone family, member V; H2A histone family, member Z; H2A.F/Z; H2A.Z variant histone 2; H2A.ZK5; H2A.ZK5ac; H2A.ZLys4ac; H2A/z; H2AFZac; H2AZ histone; H2AZK11ac; H2AZK4ac; H2AZK7ac; H2AZLys4ac; histone H2A.F/Z; Histone H2A.V; Histone H2A.Z; purine-rich binding element protein B
基因别名: H2A.z; H2A.Z-1; H2A.Z-2; H2A/z; H2AFV; H2AFZ; H2AV; H2AZ; H2AZ1; H2AZ2
UniProt ID: (Human) Q71UI9, (Human) P0C0S5
Entrez Gene ID: (Human) 94239, (Human) 3015
molecular_function
DNA binding
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
protein binding
chromatin DNA binding
nucleosomal DNA binding
histone
