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H4ac pan-acetyl (K8,K12,K16) Chimeric Antibody (MA5-48313) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of H4ac pan-acetyl (K8,K12,K16) in HeLa cells using H4ac pan-acetyl (K8,K12,K16) Chimeric Monoclonal Antibody (Product # MA5-48313). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with H4ac pan-acetyl (K8,K12,K16) Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane... View More
产品信息
MA5-48313
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
KM-2
抗原
KM-2 antibody was derived from an MRL/lpr lupus mouse.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074755
产品详细信息
Specificity: KM-2 antibody recognizes the N-terminal peptides 1-20 of histone H2A and 1-29 of histone H4 which have a large sequence homology. Histone H4 acetylation on lysines 8, 12 and 16 significantly increases the antibody's binding while the acetylation at K5 decreases it.
靶标信息
H4 acetylation at lysine residues 8, 12, and 16 is a well-characterized post-translational modification that is associated with transcriptional activation. This modification is catalyzed by histone acetyltransferases (HATs) and is often found at promoter regions of actively transcribed genes. It is believed to facilitate chromatin remodeling and transcription factor recruitment, ultimately leading to increased gene expression. However, the precise mechanisms by which H4 acetylation at these specific lysine residues contributes to gene regulation are still under investigation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H4 histone family, member A; H4 histone family, member E; H4 histone family, member I; H4 histone family, member J; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; histone 1, H4a; histone 1, H4b; histone 1, H4e; histone 1, H4i; histone 1, H4j; histone 2, H4a; Histone 4 family, member M; histone family member; Histone H4; histone IV, family 2
基因别名: dJ160A22.2; FO108; H4; H4-16; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4F2; H4F2iv; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4
UniProt ID: (Human) P62805
Entrez Gene ID: (Human) 8359, (Human) 8366, (Human) 8367, (Human) 8294, (Human) 8363, (Human) 8370
chromatin silencing at rDNA
double-strand break repair via nonhomologous end joining
nucleosome assembly
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
DNA-templated transcription, initiation
telomere capping
gene silencing by RNA
telomere organization
CENP-A containing nucleosome assembly
cellular protein metabolic process
negative regulation of megakaryocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
protein heterotetramerization
beta-catenin-TCF complex assembly
