Invitrogen

HAAO Polyclonal Antibody

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HAAO Antibody (PA5-28035) in WB

Western Blot using HAAO Polyclonal Antibody (Product # PA5-28035). Sample (50 µg of whole cell lysate). Lane A: Mouse liver. 12% SDS PAGE. HAAO Polyclonal Antibody (Product # PA5-28035) diluted at 1:10,000.

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产品信息

PA5-28035

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:10,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 1 and 258 of Human HAAO

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2545511

产品详细信息

Recommended positive controls: HepG2, mouse liver.

Predicted reactivity: Mouse (88%), Rat (90%), Pig (88%), Bovine (89%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。