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产品信息
MA5-32669
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JA11-27
抗原
Recombinant protein within Hepcidin aa 1-84
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809946
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hepcidin; LEAP-1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
基因别名: HAMP; HEPC; HFE2B; LEAP1; PLTR; UNQ487/PRO1003
UniProt ID: (Human) P81172, (Rat) Q99MH3
Entrez Gene ID: (Human) 57817, (Rat) 84604
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
immune response
response to iron ion
killing of cells of other organism
defense response to bacterium
defense response to fungus
multicellular organismal iron ion homeostasis
negative regulation of intestinal absorption
myeloid cell homeostasis
JAK-STAT cascade
negative regulation of iron ion transmembrane transport
positive regulation of macrophage activation
negative regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
iron ion homeostasis
positive regulation of cellular protein catabolic process
