Invitrogen

HBB Polyclonal Antibody

HBB Antibody in Immunocytochemistry (ICC/IF)

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HBB Antibody (PA5-60287) in ICC/IF

Immunofluorescent staining of HBB in human cell line Hep G2 using HBB Polyclonal Antibody (Product # PA5-60287) shows localization to vesicles.

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-60287

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

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免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

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免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human HBB. Recombinant protein control fragment (Product #RP-100088).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.10 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2642323

产品详细信息

Immunogen sequence: FATLSELHCD KLHVDPENFR LLGN

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

靶标信息

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon-gamma-G-gamma-A-delta-beta-3'.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.

Nature

Zhang F,Zhang B,Wang Y,Jiang R,Liu J,Wei Y,Gao X,Zhu Y,Wang X,Sun M,Kang J,Liu Y,You G,Wei D,Xin J,Bao J,Wang M,Gu Y,Wang Z,Ye J,Guo S,Huang H,Sun Q

PA5-60287 was used in Immunohistochemistry to demonstrate an extra-erythrocyte role of haemoglobin in chondrocytes, and uncover a heretofore unrecognized mechanism in which chondrocytes survive a hypoxic environment through Hedy.

Sun Oct 01 00:00:00 UTC 2023

An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.

Nature

Zhang F,Zhang B,Wang Y,Jiang R,Liu J,Wei Y,Gao X,Zhu Y,Wang X,Sun M,Kang J,Liu Y,You G,Wei D,Xin J,Bao J,Wang M,Gu Y,Wang Z,Ye J,Guo S,Huang H,Sun Q

Sun Oct 01 00:00:00 UTC 2023

An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.

Nature

Zhang F,Zhang B,Wang Y,Jiang R,Liu J,Wei Y,Gao X,Zhu Y,Wang X,Sun M,Kang J,Liu Y,You G,Wei D,Xin J,Bao J,Wang M,Gu Y,Wang Z,Ye J,Guo S,Huang H,Sun Q

Sun Oct 01 00:00:00 UTC 2023

lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta.

Molecular therapy : the journal of the American Society of Gene Therapy

Wu Y,Li P,Liu L,Goodwin AJ,Halushka PV,Hirose T,Nakagawa S,Zhou J,Liu M,Fan H

PA5-60287 was used in Immunohistochemistry to uncover a previously unknown mechanism of the Neat1/Hbb axis in regulating neuronal dysfunction, which may lead to a novel treatment strategy for SAE.