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HBEGF Antibody (PA5-143862) in IHC (P)
Immunohistochemistry analysis of HBEGF in paraffin-embedded section of human lung adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with HBEGF Polyclonal antibody (Product # PA5-143862) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Conjugated Goat Anti... View More
产品信息
PA5-143862
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human DTR/HBEGF (KKRDPCLRKYKDFCIHGECKYVKE).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3075076
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
靶标信息
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); hb egf; heparin binding epidermal growth factor-like growth factor; heparin-binding EGF-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; heparin-binding epidermal growth factor; Proheparin-binding EGF-like growth factor
基因别名: AW047313; DTR; DTS; DTSF; GFHB; Hb-egf; HBEGF; HEGFL
UniProt ID: (Human) Q99075, (Mouse) Q06186, (Rat) Q06175
Entrez Gene ID: (Human) 1839, (Mouse) 15200, (Rat) 25433
MAPK cascade
signal transduction
epidermal growth factor receptor signaling pathway
muscle organ development
regulation of heart contraction
positive regulation of cell proliferation
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
positive regulation of cell migration
wound healing, spreading of epidermal cells
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
negative regulation of elastin biosynthetic process
positive regulation of keratinocyte migration
positive regulation of protein kinase B signaling
cell chemotaxis
positive regulation of wound healing
regulation of cell motility
angiogenesis
blastocyst growth
cell migration
nervous system development
