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HCN1 Antibody (APC-056-GP200UL) in IHC
Expression of HCN1 in rat cerebellum - Immunohistochemical staining of rat cerebellum using Guinea pig Anti-HCN1 Antibody (#APC-056-GP). A. HCN1 staining (red) appears in the pinceau structures (arrows). B. DAPI is used as the counterstain (blue). C. Merged image of A and B.
产品信息
APC-056-GP200UL
产品规格
种属反应
Rat
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KPNSASNSRDDGNSVYPSK, corresponding to amino acid residues 6-24 of rat HCN1, Intracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
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生物信息学
蛋白别名: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
基因别名: Hcn1
UniProt ID: (Rat) Q9JKB0
Entrez Gene ID: (Rat) 84390
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
sodium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
protein C-terminus binding
cAMP binding
protein complex binding
identical protein binding
ion channel
transporter
regulation of membrane depolarization
inflammatory response
aging
regulation of ion transmembrane transport
cellular response to interferon-beta
sodium ion transmembrane transport
regulation of membrane potential
maternal behavior
apical protein localization
negative regulation of action potential
retinal cone cell development
response to calcium ion
cellular response to cAMP
potassium ion transmembrane transport
response to cisplatin
response to L-glutamate
regulation of membrane hyperpolarization
positive regulation of cation channel activity
