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HCN2 Antibody (APC-030-AR-50UL) in IHC
Expression of HCN2 in rat cerebellum - Immunohistochemical staining of rat cerebellum using Anti-HCN2-ATTO Fluor-594 Antibody (#APC-030-AR). A. HCN2 staining (red) appears in Purkinje neurons. B. Nuclear staining using DAPI as the counterstain (Blue). C. Merged images of A and B.
产品信息
APC-030-AR-50UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EEAGPAGEPRGSQAS, corresponding to amino acid residues 147-161 of human HCN2, Intracellular, N-terminus
偶联物
激发/发射光谱
602/622 nm
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Hyperpolarization-activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
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生物信息学
蛋白别名: BCNG-2; brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated channel 2; HAC-1; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Hyperpolarization-activated cation channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
基因别名: BCNG-2; BCNG2; HAC-1; HAC1; HCN2; trls
UniProt ID: (Human) Q9UL51, (Mouse) O88703, (Rat) Q9JKA9
Entrez Gene ID: (Human) 610, (Mouse) 15166, (Rat) 114244
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cAMP binding
identical protein binding
nucleotide binding
ion channel activity
voltage-gated ion channel activity
potassium channel activity
sodium channel activity
protein binding
PDZ domain binding
protein complex binding
protein complex scaffold
ion channel
transporter
cell-cell signaling
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
regulation of postsynaptic membrane potential
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
transport
ion transport
potassium ion transport
sodium ion transport
positive regulation of heart contraction
transmembrane transport
inflammatory response
brain development
aging
response to hormone
response to drug
cellular response to steroid hormone stimulus
response to cisplatin
