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HCN4 Antibody (APC-052-GP200UL) in IHC (F)
Multiplex staining of HCN4 and HCN2 in mouse thalamus - Immunohistochemical staining of mouse thalamus frozen section using Guinea pig Anti-HCN4 Antibody (#APC-052-GP) and rabbit Anti-HCN2 Antibody (#APC-030). A. Staining of HCN4 (green) appears in the ventral posterior thalamic nucleus (VPL). B. In the same section as in A, staining of HCN2 (red) appears in the ventral posterior thalamic nucleus (VPL) and ... View More
产品信息
APC-052-GP200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GST fusion protein with the sequence HGHLHDSAEE RRLIAEGDASPGEDRTPPGLAAEPERP, corresponding to amino acid residues 119-155 of human HCN4, Intracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCNG-3; Brain cyclic nucleotide-gated channel 3; hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
基因别名: Bcng3; Hcn3; HCN4; SSS2
UniProt ID: (Human) Q9Y3Q4, (Mouse) O70507, (Rat) Q9JKA7
Entrez Gene ID: (Human) 10021, (Mouse) 330953, (Rat) 59266
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cAMP binding
identical protein binding
nucleotide binding
ion channel activity
voltage-gated ion channel activity
potassium channel activity
sodium channel activity
protein binding
ion channel
transporter
regulation of heart rate
regulation of membrane depolarization
cation transport
muscle contraction
blood circulation
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
regulation of cardiac muscle contraction
regulation of postsynaptic membrane potential
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
SA node cell action potential
regulation of heart rate by cardiac conduction
in utero embryonic development
transport
ion transport
potassium ion transport
sodium ion transport
regulation of heart contraction
transmembrane transport
cation transmembrane transport
modulation of synaptic transmission
cellular response to steroid hormone stimulus
response to cisplatin
