Invitrogen

HDAC1 Monoclonal Antibody (10E2), FITC

查看其他40个HDAC1抗体

产品信息

MA5-46593

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent

-

流式细胞分析 (Flow)

Assay-dependent

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

10E2

抗原

Synthetic peptide: EEKPEAKGVKEEVKLA, corresponding to C terminal amino acids 467-482 of Human and mouse HDAC1

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偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

运输条件

Ambient (domestic); Wet ice (international)

AB_2937665

靶标信息

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686H12203; HD1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2

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基因别名: GON-10; HD1; HDAC1; Hdac1-ps; MommeD5; RPD3; RPD3L1

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UniProt ID: (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4

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Entrez Gene ID: (Human) 3065, (Mouse) 433759, (Rat) 297893

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transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding histone deacetylase activity protein binding transcription factor binding deacetylase activity enzyme binding nucleosomal DNA binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity activating transcription factor binding histone deacetylase binding transcription regulatory region DNA binding protein N-terminus binding NF-kappaB binding repressing transcription factor binding DNA binding chromatin binding transcription corepressor activity hydrolase activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) protein complex binding histone deacetylase activity (H4-K16 specific) Krueppel-associated box domain binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific)

negative regulation of transcription from RNA polymerase II promoter response to amphetamine transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein deacetylation endoderm development circadian rhythm positive regulation of cell proliferation negative regulation of cell proliferation epidermal cell differentiation negative regulation of gene expression positive regulation of receptor biosynthetic process chromatin modification histone deacetylation hippocampus development neuron differentiation positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production circadian regulation of gene expression cellular response to oxidative stress odontogenesis of dentin-containing tooth positive regulation of tyrosine phosphorylation of Stat3 protein embryonic digit morphogenesis ATP-dependent chromatin remodeling negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process negative regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion rhythmic process positive regulation of oligodendrocyte differentiation negative regulation of androgen receptor signaling pathway hair follicle placode formation eyelid development in camera-type eye fungiform papilla formation histone H3 deacetylation histone H4 deacetylation negative regulation of canonical Wnt signaling pathway positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of type B pancreatic cell apoptotic process negative regulation of peptidyl-lysine acetylation negative regulation of intrinsic apoptotic signaling pathway chromatin remodeling methylation-dependent chromatin silencing blood coagulation negative regulation of myotube differentiation viral process regulation of signal transduction by p53 class mediator beta-catenin-TCF complex assembly response to caffeine response to lipopolysaccharide response to drug response to hyperoxia cellular response to tumor necrosis factor