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产品信息
PA5-85101
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human HDAC6.
偶联物
形式
Liquid
浓度
0.18 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792249
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Rhesus Monkey (100%).
Positive Control: 3xFlag-human HDAC6-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ16239; HD6; HDA6; Histone deacetylase 6; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6
基因别名: CPBHM; HD6; HDAC6; JM21; KIAA0901; PPP1R90
UniProt ID: (Human) Q9UBN7
Entrez Gene ID: (Human) 10013
core promoter binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
protein polyubiquitination
transcription, DNA-templated
protein deacetylation
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
organelle organization
negative regulation of microtubule depolymerization
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
positive regulation of receptor biosynthetic process
macroautophagy
histone deacetylation
regulation of protein stability
lysosome localization
peptidyl-lysine deacetylation
cellular response to topologically incorrect protein
regulation of gene expression, epigenetic
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
negative regulation of oxidoreductase activity
mitochondrion localization
response to misfolded protein
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
regulation of establishment of protein localization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
Hsp90 deacetylation
response to growth factor
histone H3 deacetylation
cellular response to misfolded protein
positive regulation of chaperone-mediated protein complex assembly
tubulin deacetylation
mitophagy in response to mitochondrial depolarization
positive regulation of hydrogen peroxide-mediated programmed cell death
regulation of mitophagy
