Invitrogen

HDAC6 Polyclonal Antibody

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HDAC6 Antibody in Immunocytochemistry (ICC/IF)

HDAC6 Antibody in Immunocytochemistry (ICC/IF)

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HDAC6 Antibody (PA5-88129) in ICC/IF

Immunofluorescence analysis of HDAC6 in U2OS cells. Samples were incubated with HDAC6 Polyclonal antibody (Product # PA5-88129).

HDAC6 Antibody in Immunocytochemistry (ICC/IF)

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HDAC6 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence analysis of HDAC6 in U2OS cells. Samples were incubated with HDAC6 Polyclonal antibody (Product # PA5-88129).

产品信息

PA5-88129

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:200

-

酶联免疫吸附实验 (ELISA)

1 µg/mL

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 160-470 of human HDAC6 (NP_0060352)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.52 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2804673

产品详细信息

Immunogen sequence: NEGELRVLAD TYDSVYLHPN SYSCACLASG SVLRLVDAVL GAEIRNGMAI IRPPGHHAQH SLMDGYCMFN HVAVAARYAQ QKHRIRRVLI VDWDVHHGQG TQFTFDQDPS VLYFSIHRYE QGRFWPHLKA SNWSTTGFGQ GQGYTINVPW NQVGMRDADY IAAFLHVLLP VALEFQPQLV LVAAGFDALQ GDPKGEMAAT PAGFAQLTHL LMGLAGGKLI LSLEGGYNLR ALAEGVSASL HTLLGDPCPM LESPGAPCRS AQASVSCALE ALEPFWEVLV RSTETVERDN MEEDNVEESE EEGPWEPPVL P

靶标信息

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ16239; HD6; HDA6; histone deacetylase 5; Histone deacetylase 6; Histone deacetylase mHDA2; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; scurfy candidate 6; Tubulin-lysine deacetylase HDAC6

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基因别名: CPBHM; HD6; Hdac5; HDAC6; JM21; KIAA0901; mHDA2; PPP1R90; Sfc6

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UniProt ID: (Human) Q9UBN7, (Mouse) Q9Z2V5

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Entrez Gene ID: (Human) 10013, (Mouse) 15185

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core promoter binding actin binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding enzyme binding polyubiquitin binding ubiquitin protein ligase binding NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding dynein complex binding hydrolase activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) ubiquitin binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme

protein polyubiquitination transcription, DNA-templated protein deacetylation misfolded or incompletely synthesized protein catabolic process intracellular protein transport organelle organization negative regulation of microtubule depolymerization response to toxic substance positive regulation of signal transduction response to organic substance regulation of receptor activity regulation of autophagy positive regulation of epithelial cell migration negative regulation of hydrogen peroxide metabolic process positive regulation of receptor biosynthetic process macroautophagy histone deacetylation regulation of protein stability lysosome localization peptidyl-lysine deacetylation cellular response to topologically incorrect protein regulation of gene expression, epigenetic ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein complex disassembly negative regulation of protein complex disassembly regulation of fat cell differentiation negative regulation of proteolysis negative regulation of transcription, DNA-templated negative regulation of oxidoreductase activity mitochondrion localization response to misfolded protein regulation of microtubule-based movement regulation of androgen receptor signaling pathway regulation of establishment of protein localization cellular response to hydrogen peroxide aggresome assembly polyubiquitinated misfolded protein transport Hsp90 deacetylation response to growth factor histone H3 deacetylation cellular response to misfolded protein positive regulation of chaperone-mediated protein complex assembly tubulin deacetylation mitophagy in response to mitochondrial depolarization positive regulation of hydrogen peroxide-mediated programmed cell death regulation of mitophagy regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process chromatin modification