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HELLS Antibody (PA5-96440) in WB
Western blot analysis of HELLS in extracts of various cell lines. Samples were incubated with HELLS Polyclonal antibody (Product # PA5-96440) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-96440
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 719-838 of human Lsh/HELLS (NP_0605332)
偶联物
形式
Liquid
浓度
0.51 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808242
产品详细信息
Immunogen sequence: VYRLVTANTI DQKIVERAAA KRKLEKLIIH KNHFKGGQSG LNLSKNFLDP KELMELLKSR DYEREIKGSR EKVISDKDLE LLLDRSDLID QMNASGPIKE KMGIFKILEN SEDSSPECLF; Positive Samples: MCF-7, A549, 293T, HepG2, Mouse thymus; Cellular Location: Nucleus
靶标信息
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: helicase, lymphoid specific; hells; Lymphocyte-specific helicase; Lymphoid-specific helicase; Proliferation-associated SNF2-like protein; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6; TBC1D12: TBC1 domain family, member 12
基因别名: AI323785; E130115I21Rik; HELLS; ICF4; LSH; Lysh; Nbla10143; PASG; SMARCA6; Tbc1d12; YFK8
UniProt ID: (Human) Q9NRZ9, (Mouse) Q60848
Entrez Gene ID: (Human) 3070, (Mouse) 15201, (Rat) 294071
urogenital system development
DNA methylation
chromatin silencing
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
mitotic nuclear division
multicellular organism development
maintenance of DNA methylation
lymphocyte differentiation
pericentric heterochromatin assembly
negative regulation of apoptotic process
cell division
negative regulation of intrinsic apoptotic signaling pathway
lymphocyte proliferation
