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HERC5 Antibody (PA5-100555) in IHC (P)
Immunohistochemistry analysis of HERC5 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with HERC5 polyclonal antibody (Product # PA5-100555) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100555
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HERC5(Accession Q9UII4), corresponding to amino acid residues G303-E353.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850064
产品详细信息
Antibody detects endogenous levels of total HERC5.
靶标信息
HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; probable E3 ubiquitin-protein ligase HERC5
基因别名: CEB1; CEBP1; HERC5
UniProt ID: (Human) Q9UII4
Entrez Gene ID: (Human) 51191
regulation of cyclin-dependent protein serine/threonine kinase activity
protein polyubiquitination
ISG15-protein conjugation
negative regulation of type I interferon production
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
innate immune response
regulation of defense response to virus
defense response to virus
