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产品信息
MA5-26301
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI1A2
抗原
Full length human recombinant protein of HERPUD1 produced in HEK293T cell
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2724440
靶标信息
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Methyl methanesulfonate (MMF)-inducible fragment protein 1; MMS-inducible
基因别名: HERP; HERPUD1; KIAA0025; MIF1; SUP
UniProt ID: (Human) Q15011
Entrez Gene ID: (Human) 9709, (Rat) 85430
ubiquitin-dependent protein catabolic process
cellular calcium ion homeostasis
response to unfolded protein
endoplasmic reticulum unfolded protein response
regulation of protein ubiquitination
positive regulation of protein binding
endoplasmic reticulum calcium ion homeostasis
response to endoplasmic reticulum stress
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of intrinsic apoptotic signaling pathway
retrograde protein transport, ER to cytosol
PERK-mediated unfolded protein response
