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HERV-FRD Antibody (PA5-109694) in WB
Western blot analysis of HERV-FRD in extracts of 293T cells. Samples were incubated with HERV-FRD Polyclonal antibody (Product # PA5-109694) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-109694
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 16-250 of human ERVFRD-1 (NP_997465.1).
Conjugate
Form
Liquid
Concentration
2.66 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855105
Product Specific Information
Immunogen sequence: AYRHPDFPLL EKAQQLLQST GSPYSTNCWL CTSSSTETPG TAYPASPREW TSIEAELHIS YRWDPNLKGL MRPANSLLST VKQDFPDIRQ KPPIFGPIFT NINLMGIAPI CVMAKRKNGT NVGTLPSTVC NVTFTVDSNQ QTYQTYTHNQ FRHQPRFPKP PNITFPQGTL LDKSSRFCQG RPSSCSTRNF WFRPADYNQC LQISNLSSTA EWVLLDQTRN SLFWENKTKG ANQSQ
Target Information
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endogenous retrovirus group FRD member 1; endogenous retrovirus group FRD, member 1; Envelope polyprotein; FLJ41944; FLJ90611; HERV-FRD; HERV-FRD provirus ancestral Env polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; MGC87585; Synb; syncytin 2; Syncytin-2; Syncytin2
Gene Aliases: envFRD; ERVFRD-1; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD; UNQ6191; UNQ6191/PRO20218
UniProt ID: (Human) P60508
Entrez Gene ID: (Human) 405754
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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