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产品信息
MA5-17089
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
3F10
抗原
Purified recombinant fragment of human HEXA expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538560
产品详细信息
MA5-17089 targets HEXA in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17089 immunogen is purified recombinant fragment of human HEXA expressed in E. Coli.
MA5-17089 detects HEXA which has a predicted molecular weight of approximately 60.7kDa.
靶标信息
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
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生物信息学
蛋白别名: Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; EC 3.2.1; EC 3.2.1.52; hexosaminidase A (alpha polypeptide); Hexosaminidase subunit A; MGC99608; N-acetyl-beta-glucosaminidase subunit alpha
基因别名: Hex-1; HEXA; TSD
UniProt ID: (Human) P06865, (Mouse) P29416
Entrez Gene ID: (Human) 3073, (Mouse) 15211
carbohydrate metabolic process
glycosaminoglycan biosynthetic process
glycosphingolipid metabolic process
chondroitin sulfate catabolic process
hyaluronan catabolic process
keratan sulfate catabolic process
skeletal system development
ganglioside catabolic process
lysosome organization
sensory perception of sound
locomotory behavior
adult walking behavior
metabolic process
lipid storage
sexual reproduction
glycosaminoglycan metabolic process
myelination
cell morphogenesis involved in neuron differentiation
neuromuscular process controlling posture
neuromuscular process controlling balance
SMAD protein signal transduction
